免疫学——石琦

　　一、个人简介

　　石琦，博士，研究员，博士生导师，中国疾病预防控制中心病毒病所朊病毒病室负责人，传染病溯源预警与智能决策全国重点实验室PI，长期从事全国人类朊病毒病的监测及相关研究工作。

　　兼任中国微生物学会病毒学专业委员会委员、中国微生物学会微生物生物安全专业委员会常务委员、中国医疗保健国际交流促进会常务委员、中国初级卫生保健基金会病原检测专业委员会委员等学术职务。

　　已主持并完成两项国家自然科学基金项目，主持及参与了多项国家级课题项目的研究；2021年以第二完成人获得“中华预防医学会科学技术奖二等奖”；2020年以第二完成人获得“华夏医学科技奖二等奖”；2009年以第五完成人获得“中华预防医学会科学技术奖二等奖”；目前以第一作者/通讯作者发表中英文论文130余篇，其中SCI收录英文期刊上发表论文70余篇，同时担任《Neurodegeneration》杂志及《Zoonoses》杂志科学编委、《疾病监测》杂志及《中国病毒病杂志》编委。

　　二、主要研究方向

　　1、朊病毒病慢性感染及跨种属传播机制；

　　2、朊病毒病蛋白组学、转录组学及代谢组学相关研究；

　　3、朊病毒新型诊断技术的建立及应用研究。

　　三、代表性论文、成果

　　1.Wu YZ, Gao LP, Chen DD, Liang DL, Chen J, Xiao K, Hu C, Chen C, Shi Q, Dong XP. Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease. Neurobiol Aging, 2023, 131:156-169

　　2.Chen DD, Jiao L, Huang Y, Xiao K, Gao LP, Chen C, Shi Q, Dong XP. Application of α-Syn RT-QuIC for brain and skin specimens of the Chinses patients with Parkinson disease. Front Aging Neurosci, 2022, 14:898516

　　3.Chen DD, Jiao L, Huang Y, Xiao K, Gao LP, Chen C, Shi Q, Dong XP. Application of α-Syn RT-QuIC for brain and skin specimens of the Chinses patients with Parkinson disease. Front Aging Neurosci, 2022, 14:898516

　　4.Xiao K, Yang XH, Zhou W, Chen C, Shi Q, Dong XP. Validation and application of skin RT-QuIC to patients in China with probable CJD. Pathogen, 2021, 10:1642

　　5.Shi Q, Chen C, Xiao K, Zhou W, Gao LP, Chen DD, Wu YZ, Wang Y, Hu Chao, Gao C, Dong XP. Genetic prion disease: insight of the features and experience of China National Surveillance for Creutzfeldt-Jakob disease. Neurosci Bulletin, 2021, 37(11):1570-1582

　　6.Maimaitiming A, Xiao K, Hu C, Chen J, Yang XH, Zhou DH, Gao LP, Dong XP, Shi Q. Aberrant decrease of the endogenous SIRT3 and increases of acetylated proteins in scrapie infected cell line SMB-S15 and in the brains of experimental mice. ACS Chemical Neuroscience, 2019, 10(10):4293-4302(IF:4.21)

　　7.Shi Q, Zhou W, Chen C, Xiao K, Wang Y, Gao C, Dong XP. Rare genetic Creutzfeldt-Jakob disease with T188K mutation: analysis of clinical, genetic and laboratory features of thirty Chinese patients. J Neurol Neurosurg Ps,2017,88 (10):889-890(IF:7.349).

　　8.Shi Q, Zhou W, Chen C, Zhang BY, Xiao K, Zhang XC, Shen XJ, Li Q, Deng LQ, Dong JH, Lin WQ, Huang P, Jiang WJ, Lv J, Han J, Dong XP. The features of genetic prion diseases based on Chinese surveillance program. PLoS One, 2015, 10:e0139552.

　　9.Shi Q, Li-Na Chen, Bao-Yun Zhang, Kang Xiao, Wei Zhou, Cao Chen, Xiao-Mei Zhang, Chan Tian, Chen Gao, Jing Wang, Jun Han, Xiao-Ping Dong. Proteomics analyses for the global proteins in the brain tissues of different human prion diseases. Mol Cell Proteomics, 2015,14(4):854-69 (IF:7.254)

　　10.Shi Q, Song QQ, Sun P, Zhang J, Song J, Chen LN, Xiao K, Wang SB, Zhang YZ, Li GQ, Sheng LJ, Wang BD, Lu MZ, Han J, Dong XP. Infection of prions and treatment of PrP106-126 alter the endogenous status of protein 14-3-3 and trigger the mitochondrial apoptosis possibly via activating Bax pathway. Mol Neurobiol. 2014, 49(2):840-51