病原生物学——何小周

　　一、个人简介

　　何小周，男，1987年出生，博士，副研究员，硕士生导师。传染病溯源预警与智能决策全国重点实验室，医学病毒学国家重点实验室，中国疾病预防控制中心病毒病预防控制所。长期专注于新发和突发传染病的病原体检测监测技术研究、疾病预防控制及免疫学相关研究，建立了高通量测序技术及病毒宏基因组分析平台，开展不明原因感染性疾病的病原学检测技术研究，从事野生动物、媒介生物以及复杂环境新病原监测等相关研究，同时关注多载体疫苗相关技术及接种策略研究。多次参与抗击新冠疫情应急任务，担任WHO-中国联合新冠溯源专家，中国疾控中心援鄂抗疫前方专家，中国疾控中心绥芬河、哈尔滨、舒兰应急检测专家，中国疾控中心新冠疫情防控国家专家队专家，科技部溯源专班专家，国家疾病预防控制局新冠流调溯源和监测预警专班专家；援塞拉利昂生物安全实验室项目专家；近年主持或参与多项国家科技重大专项和国家重点研发等国家、省部级课题；近年发表SCI论文20余篇；编写卫生行业标准1项；申请专利授权5项；中国医疗保健国际交流促进会分子诊断学分会委员；Medicine Advances期刊青年编委。

　　二、主要研究方向

　　新发和突发病毒的检测和监测技术，疾病预防控制，多载体疫苗技术和免疫接种策略。

　　三、代表性论文、成果（不超过10篇）

　　[1] He, X. and X. Wang, et al. (2022). "Metagenomic analysis of viromes in tissues of wild Qinghai vole from the eastern Tibetan Plateau." Scientific Reports 12 (1): 17239.

　　[2] He, X. and Q. Yin, et al. (2021). "Metagenomic sequencing reveals viral abundance and diversity in mosquitoes from the Shaanxi-Gansu-Ningxia region, China." PLoS Negl Trop Dis 15 (4): e0009381.

　　[3] He, X. and W. Wang, et al. (2017). "Evaluation of the efficacy of a therapeutic HIV vaccine by in vitro stimulation assay." Cell Immunol.

　　[4] He, X. and S. Wang, et al. (2013). "Changes in age distribution of hemorrhagic fever with renal syndrome: an implication of China's expanded program of immunization." BMC Public Health 13: 394.

　　[5] Fan, G. and He, X, et al. (2023). "RNA-sequencing-based detection of human viral pathogens in cerebrospinal fluid  and serum samples from children with meningitis and encephalitis." Microb Genom 9 (8).

　　[6] Fan, G. and X. He, et al. (2023). "A rapid and highly sensitive multiple detection of human adenovirus type 3, type  7 and respiratory syncytial virus by recombinase-aided reverse transcription PCR." J Clin Lab Anal 37 (7): e24889.

　　[7] Li, Y. and X. Z. He, et al. (2020). "Comparison of third-generation sequencing approaches to identify viral pathogens  under public health emergency conditions." Virus Genes 56 (3): 288-297.

　　[8] Wang, J. and X. Z. He, et al. (2020). "Multiple-centre clinical evaluation of an ultrafast single-tube assay for SARS-CoV-2 RNA." Clin Microbiol Infect..

　　[9] Lin, Y. and X. He, et al. (2023). "Cold-chain-based epidemiology: Scientific evidence and logic in introduction and transmission of SARS-CoV-2." Global Transitions 5: 170-181.