病原生物学——严冬梅

　　一、个人简介

　　严冬梅，女，中国疾病预防控制中心病毒病预防控制所研究员，病原生物学硕士研究生导师。本科毕业于中国医科大学临床专业，硕士毕业于北京大学医学部病原生物学专业。主要从事脊髓灰质炎，手足口病和出血性结膜炎等肠道病毒病预防控制相关的应用基础和基础研究，国内外期刊发表论文数十篇。曾在美国疾病预防控制中心肠道室及日本国立感染症研究所病毒二部做访问学者。中华预防医学会生物资源管理与利用研究分会委员，中华预防医学会感染性疾病防控分会青年委员。曾荣获中华医学会三等奖和中华预防医学会二等奖。主持过国家自然基金青年基金和面上项目（81101303和81373049），十三五重大专项“基于全基因组的病毒网络化监测和溯源技术体系研究”课题组副组长，主持子课题“高度散发和环境传播病毒全基因组数据库的建立和分子分型标准化方法的研究、质量控制和推广应用”，重点研发项目“微生物科学数据管理与挖掘关键技术与应用”任务负责人。

　　二、主要研究方向

　　主要从事脊髓灰质炎，手足口病和出血性结膜炎等肠道病毒病预防控制相关的应用基础和基础研究。

　　三、代表性论文、成果

　　1. Genetic characterization and molecular evolution of type 3 vaccine-derived polioviruses from an immunodeficient patient in China. Qin Guo, Shuangli Zhu, Dongyan Wang, Xiaolei Li, Hui Zhu, Yang Song, Xiaoqing Liu, Fang Xiao, Hehe Zhao, Huanhuan Lu, Jinbo Xiao, Liheng Yu, Wenhui Wang, Yun He, Ying Liu, Jichen Li, Yong Zhang, Wenbo Xu, Dongmei Yan. Virus Research 2023 Sep:334:199177.

　　2. Molecular analysis of Coxsackievirus A24 variant isolates from three outbreaks of acute hemorrhagic conjunctivitis in 1988, 1994 and 2007 in Beijing, China. Junhan Li，Fang Huang，Yong Zhang，Tianjiao Ji,，Shuangli Zhu，Dongyan Wang，Zhenzhi Han，Jinbo Xiao，Fenfen Si，Wenbo Xu，Dongmei Yan. Virol Sin. 2022 Jan 22;S1995-820X(22)00024-4. doi: 10.1016/j.virs.2022.01.024

　　3. Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study. Fenfen Si , Dongyan Wang , Tianjiao Ji , Yong Zhang , Shuangli Zhu , Junhan Li  , Wenbo Xu, Zexin Tao , Dongmei Yan. Virology Journal (2022) 19:83. 4. Molecular Epidemiology and Evolution of Coxsackievirus A9. Hehe Zhao , Jianxing Wang , Jianhua Chen , Ruifang Huang , Yong Zhang , Jinbo Xiao , Yang Song , Tianjiao Ji  , Qian Yang , Shuangli Zhu , Dongyan Wang , Huanhuan Lu , Zhenzhi Han , Guoyan Zhang , Jichen Li  , Dongmei Yan. Viruses 2022 Apr 15;14(4):822.

　　5. Origin and evolution analysis and genetic characteristics of echovirus 9 in China. Fenfen Si，Tianjiao Ji，Dongyan Wang，Yong Zhang，Shuangli Zhu，Junhan Li，Wenbo Xu，Dongmei Yan. Virol J. 2022 Jun 3;19(1):98.

　　6.Genetic characterization and molecular epidemiology of Coxsackievirus A12 from mainland China during 2010-2019. Qin Guo, Hehe Zhao, Yong Zhang, Xianjun Wang, Qiuli Yu, Zhaolin Tan, Huanhuan Lu, Jinbo Xiao, Tianjiao Ji, Shuangli Zhu, Dongyan Wang, Qian Yang, Zhenzhi Han, Wenbo Xu, Dongmei Yan. Front Microbiol. 2022 Dec 21;13:988538.

　　7. Implication of a High Risk of Type 2 Vaccine-Derived Poliovirus Emergence and Transmission after the Switch from tOPV to bOPV. Dongmei Yan, Dongyan Wang, Yong Zhang, Xiaolei Li, Haishu Tang, Jing Guan, Yang Song, Shuangli Zhu, Wenbo Xu . J Infect Dis.2021 Jan 4;223(1):113-118. doi: 10.1093/infdis/jiaa386.

　　8. Circulation of Type 2 Vaccine-Derived Poliovirus in China in 2018-2019.Zhao H,  Ma X,  Tang H,  Zhang Y,  Chen N,  Kaisaier W, Wang Q,  Wang C,  Zhu S, Qi Q, Liu Y,  Ma Q,  Yang Q,  Li J,  Wang D, Li X, Xiao J, Zhu H,  Xu W, Tong W, DONGMEI YAN. Open Forum Infect Dis.2021.

　　9. Immunogenicity of Oral Polio Vaccine and Salk Inactive Polio Vaccine Against Xinjiang Imported Type 1 Wild Poliovirus Yan D,Wang D,Zhu S,Zhang Y,Li X,Tang H,Guan J,Xu WENBO.. Clin Infect Dis.2020 Apr 15;70(9):1980-1984. doi: 10.1093/cid/ciz549.