病原生物学——高荣保

　　一、个人简介

　　高荣保，男，医学博士，研究员，博士研究生导师。自2006年以来，一直从事流感病毒监测及其防控相关研究。先后主持和参与包括国家自然科学基金面上项目、国家重点研发专项、国家科技支撑课题和国家艾滋病和病毒性肝炎等重大传染病防治专项在内等国家课题10余项。分别在流感病毒的感染病原学、检测方法学、病原进化、致病特征及机制等方面开展了系列研究工作，作为主要参与人先后发现并确认全球首例人感染H7N9、H10N8和H5N6禽流感病毒病例。

　　共发表科技期刊论文60余篇，其中SCI收录期刊论文40余篇。获发明专利2项，先后获得国家科技奖特等奖、中华预防医学会科学技术奖一等奖、中华医学会科学技术奖一等奖、中华预防医学会科学技术奖二等奖、国家卫计委“援非抗埃”嘉奖等奖项多项。兼任BMC infectious disease编委和中华临床实验和病毒学杂志通讯编委、国家自然科学基金和北京市自然科学基金通讯评审专家等。

　　二、主要研究方向

　　1、病毒感染与免疫损伤

　　2、流感病毒及感染

　　3、新发突发病毒性传染病

　　三、代表性论文、成果

　　1.J. He, S. Hou, Y. Chen, J.L. Yu, Q.Q. Chen, L. He, J. Liu, L. Gong, X.E. Huang, J.B. Wu, H.F. Pan, and R.B. Gao, The Epidemiological Pattern and Co-infection of Influenza A and B by Surveillance Network From 2009 to 2014 in Anhui Province, China. Front Public Health 10 (2022) 825645.

　　2.Zhao D, Yao F, Wang L, Zheng L, Gao Y, Ye J, Guo F, Zhao H, Gao R.A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias.Clin Infect Dis. 2020 Jul 28;71(15):756-761. doi: 10.1093/cid/ciaa247.

　　3.Zhang W, Zhao K, Jin J, He J, Zhou W, Wu J, Tang R, Ma W, Ding C, Liu W, Zhang L, Gao R.A hospital cluster combined with a family cluster of avian influenza H7N9infection in Anhui Province, China. J Infect. 2019 Jul;79(1):49-55. doi: 10.1016/j.jinf.2019.05.008.

　　4.Gao R, Wang L, Bai T, Zhang Y, Bo H, Shu Y: C-Reactive Protein Mediating Immunopathological Lesions: A Potential Treatment Option for Severe Influenza A Diseases.EBioMedicine 2017, 22:133-42.

　　5.Gao R, Bai T, Li X, Xiong Y, Huang Y, Pan M, Zhang Y, Bo H, Zou S, Shu Y: The comparison of pathology in ferrets infected by H9N2 avian influenza viruses with different genomic features. Virology.2016, 488:149-55.

　　6.Gao R, Pan M, Li X, Zou X, Zhao X, Li T, Yang H, Zou S, Bo H, Xu J, Li S, Zhang M, Li Z, Wang D, Zaki SR, Shu Y: Post mortem findings in a patient with avian influenza A (H5N6) virus infection. Clin Microbiol Infect. 2016 Mar 31. pii: S1198-743X(16)30033-7.

　　7.Gao R, Bhatnagar J, Blau DM, Greer P, Rollin DC, Denison AM, Deleon-Carnes M, Shieh WJ, Sambhara S, Tumpey TM, Patel M, Liu L, Paddock C, Drew C, Shu Y, Katz JM, Zaki SR.Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis.Am J Pathol. 2013 Oct;183(4):1258-68. doi: 10.1016/j.ajpath.2013.06.023. Epub 2013 Aug 11.

　　8.Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai T, Wang S, Hao P, Yang W, Zhang Y, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan Z, Shu Y. Human infection with a novel avian-origin influenza A (H7N9) virus.N Engl J Med. 2013 May 16;368(20):1888-97. doi: 10.1056/NEJMoa1304459.

　　9.Zhou J, Wang D, Gao R, Zhao B, Song J, Qi X, Zhang Y, Shi Y, Yang L, Zhu W, Bai T, Qin K, Lan Y, Zou S, Guo J, Dong J, Dong L, Zhang Y, Wei H, Li X, Lu J, Liu L, Zhao X, Li X, Huang W, Wen L, Bo H, Xin L, Chen Y, Xu C, Pei Y, Yang Y, Zhang X, Wang S, Feng Z, Han J, Yang W, Gao GF, Wu G, Li D, Wang Y, Shu Y.Biological features of novel avian influenza A (H7N9) virus.Nature. 2013 Jul 25;499(7459):500-3. doi: 10.1038/nature12379. Epub 2013 Jul 3. (Co-first author)

　　10.Chen H, Yuan H, Gao R, Zhang J, Wang D, Xiong Y, Fan G, Yang F, Li X, Zhou J, Zou S, Yang L, Chen T, Dong L, Bo H, Zhao X, Zhang Y, Lan Y, Bai T, Dong J, Li Q, Wang S, Zhang Y, Li H, Gong T, Shi Y, Ni X, Li J, Zhou J, Fan J, Wu J, Zhou X, Hu M, Wan J, Yang W, Li D, Wu G, Feng Z, Gao GF, Wang Y, Jin Q, Liu M, Shu Y. Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study.Lancet. 2014 Feb 22;383(9918):714-21. doi: 10.1016/S0140-6736(14)60111-2. Epub 2014 Feb 5. (Co-first author)