病原生物学——朱武洋

　　一、个人简介

　　朱武洋，博士，研究员，博士生导师。国家狂犬病工作委员会副主任委员，卫健委狂犬病疫苗处置工作专家组成员，国家免疫规划技术专家组成员，传染病溯源预警与智能决策全国重点实验室独立PI。主要从事狂犬病预防控制相关的应用基础和基础研究及狂犬病病毒、甲病毒相关的反向遗传研究。已发表核心期刊以上论文一百五十余篇，其中第一作者或通讯作者SCI论文四十余篇。荣获卫生部、中宣部、外交部等七部委联合颁发的援非抗击埃博拉“先进个人”称号，获得省部级一等奖一项，二等奖二项。作为主持人或分课题主持人先后承担国家自然基金、国家科技重大专项、全国重点实验室等总共十余项国家级课题。

　　二、主要研究方向

　　1. 狂犬病分子流行病学及检测技术研究；

　　2. 狂犬病病毒分子致病机制及抗病毒药物筛选；

　　3.狂犬病病毒、甲病毒相关的反向遗传研究

　　三、代表性论文、成果

　　1.Shuqing Liu , Yuan Xie, Xin Gao, Qian Wang and Wu Yang Zhu. Infammatory response and MAPK and NF-κB pathway activation induced by natural street rabies virus infection in the brain tissues of dogs and humans. Virology Journal. 2020, 17: 157;

　　2.Li H, Liu JJ, Ding SJ, Cai L, Feng Y, Yu PC, Liu SQ, Lu XX, Tao XY, Zhu WY. Human rabies in China: evidence-based suggestions for improved case detection and data gathering. Infectious diseases of poverty. 2020, 9(1): 60;

　　3.Shuqing Liu, Xin Gao, Yuan Xie, Qian Wang and Wu Yang Zhu. Rabies viruses of different virulence regulates inflammatory responses both in vivo and in vitro via MAPK and NF-κB pathway. Molecular Immunology. 2020, 125: 70-82;

　　4.Tao XY, Li ML, Wang Qian, Baima C, Hong M, Li W, Wu YB, Li YR, Zhao YM, Rayner S, and Zhu WY. The reemergence of human rabies and emergence of an Indian subcontinent lineage in Tibet, China.PLoS Neglected Tropical Diseases. 2019, 13(1): e0007036;

　　5.William J. Liu ,Weifeng Shi, Wuyang Zhu (Co-corresponding) et al. Intra-host Ebola viral adaption during human infection. Biosafety and Health, 2019(1): 12-14.

　　6.Pengcheng Yu, Jianghong Yan, Weicheng Wu, Xiaoyan Tao, Xuexin Lu, Shuqing Liu and Wuyang Zhu；A CpG oligodeoxynucleotide enhances theimmune response to rabies vaccination inmice; Virology Journal; 2018, 15: 174;

　　7.Pengcheng Yu, Jianghong Yan, Weicheng Wu, Xiaoyan Tao, Xuexin Lu, Shuqing Liu and Wuyang Zhu；Establishment of a Chinese street rabiesvirus library and its application for detecting neutralizing activity; Infectious Diseases of Poverty; 2018, doi.org/10.1186/s40249-018-0500-x;

　　8.Xiao-Yan Tao, Mu-Li Li, Zhen-Yang Guo,Jiang-Hong Yan,and Wu-Yang Zhu；Inner Mongolia:A Potential Portal for the Spreadof Rabies to Western China；Vector-borne and Zoonotic Diseases; 2018, DOI: 10.1089/vbz.2017.2248;

　　9.Xue-Xin Lu, Wu-Yang Zhu (Co-corresponding) and Gui-Zhen Wu; Rabies virus transmission via solid organsor tissue allotransplantation; Infectious Diseases of Poverty; 2018, 7:82;

　　10.Shuqing Liu, Hong Jia, Shaohua Hou, Ting Xin, Xiaoyu Guo, Gaimei Zhang, Xintao Gao, Ming Li,Wuyang Zhu (Co-corresponding) and Hongfei Zhu; Recombinant Mtb9.8 of Mycobacterium bovis stimulates TNF-α and IL-1β secretion by RAW264.7 macrophages through activation of NF-κB pathway via TLR2;Scientific Reports. 2018, 8: 1928.