免疫学——陈操

　　一、个人简介

　　陈操，博士，研究员，博士研究生导师。2014年毕业于中国疾病预防控制中心免疫学专业，获医学博士学位。现任中国疾病预防控制中心病毒病预防控制所所长助理、疾病控制（应急）办公室主任，国家卫生健康委医学病毒和病毒病重点实验室副主任，传染病溯源预警与智能决策全国重点实验室PI、病毒性传染病研究北京市重点实验室PI。兼任中华预防医学会医防协同医防融合工作委员会秘书长、中国疫苗行业协会水痘和带疱防控分会副主任委员、中国医疗保健国际交流促进会分子诊断学分会常务委员。国家健康科普专家库成员、北京健康科普专家、《Zoonoses》和《中华实验和临床病毒学杂志》编委。

　　主要研究领域包括新冠病毒变异株监测和预警研究、新发传染病病原学研究和朊病毒致病机制研究。主持国家自然科学基金、国家重点研发计划、传染病预防控制国家重点实验室等10余项课题，参与科研项目20余项。发表第一或通讯作者SCI收录论文30余篇，参编著作3本。近五年，获北京市科技进步一等奖等省部级科技奖项3项，获国家卫健委颁发的“个人嘉奖”、“个人突出贡献奖”和“优秀共产党员”等荣誉称号，获“中国好医生、中国好护士”2023年2月月度人物。曾于国家疾控局监测预警专班和中国疾控中心监测预警专班工作。

　　二、主要研究方向

　　1.新发传染病监测预警研究

　　2.新发传染病病原学研究

　　3.朊病毒致病机制研究

　　三、代表性论文、成果

1.Chen C, Dong XP. Unlocking Neuroinflammation: A Balanced Art for Therapeutics of Prion Disease. ACS Chem Neurosci. 2025 Feb 5;16(3):281-283.

2.Jia XX*, Chen C*#, Hu C, Wu YZ, Chao ZY, Zeng JF, A RH, Zhou DH, Wang Y, Zhang WW, Xiao K, Gao LP, Shi Q, Dong XP. Aberrance of GAP43/p-GAP43 Closely Associates with the Pathology of Neuron Loss in Prion-Infected Rodent Models. Mol Neurobiol. 2025 Apr;62(4):4435-4451. *Co-first author. #Corresponding author.

3.Feng YN, Zhao X, Chen ZX, Wu YC, Li LL, Wu CC, Nie K, Yang XY, Niu PH, Wang J, Wang SW, Chen C#. Prevalence and diversity of imported severe acute respiratory syndrome coronavirus 2 variants in China, 2021-2022. J Med Virol. 2024 May;96(5):e29664. #Corresponding author.

4.Jia XX*, Chen C*#, Hu C, Chao ZY, Zhang WW, Wu YZ, Fan Q, A RH, Liu X, Xiao K, Shi Q, Dong XP#. Abnormal Changes of IL3/IL3R and Its Downstream Signaling Pathways in the Prion-Infected Cell Line and in the Brains of Scrapie-Infected Rodents. Mol Neurobiol. 2024 Dec;61(12):9756-9775. *Co-first author. #Corresponding author.

5.Chen C*, Feng Y*, Chen Z, Xia Y, Zhao X, Wang J, Nie K, Niu P, Han J, Xu W. SARS-CoV-2 cold-chain transmission: Characteristics, risks, and strategies. J Med Virol. 2022 Aug;94(8):3540-3547. *Co-first author.

6.Xia Y*, Chen C*#, Chen J, Hu C, Yang W, Wang L, Liu L, Gao LP, Wu YZ, Chen DD, Shi Q, Chen ZB, Dong XP. Enhanced M-CSF/CSF1R Signaling Closely Associates with PrPSc Accumulation in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents. Mol Neurobiol. 2022 59(10):6534-6551. *Co-first author. #Corresponding author.

7.Hu C*, Chen C*#, Xia Y, Chen J, Yang W, Wang L, Chen DD, Wu YZ, Fan Q, Jia XX, Xiao K, Shi Q, Chen ZB, Dong XP. Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents. Front Cell Dev Biol. 2022;10:844378. *Co-first author. #Corresponding author.

8.Yang W*, Chen C*#, Chen J, Xia Y, Hu C, Wang L, Wu YZ, Shi Q, Chen ZB, Dong XP. PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways. Mol Neurobiol. 2022; 59(5):3310-3321. *Co-first author. #Corresponding author.

9.Hu C*, Chen C*#, Dong XP. Impact of COVID-19 Pandemic on Patients With Neurodegenerative Diseases. Front Aging Neurosci. 2021 Apr 8; 13: 664965. *Co-first author. #Corresponding author.

10.Chen C*, Hu C*, Zhou W, Chen J, Shi Q, Xiao K, Wang Y, Dong XP. Calmodulin level is significantly increased in the cerebrospinal fluid of patients with sporadic Creutzfeldt-Jakob disease. Eur J Neurol. 2021, 28(4): 1134-1141. *Co-first author.